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Canakinumab an Firsekibart, a humanized IL-1 monoclonal antibody, specifically binds to IL-1 , blocking its interaction with receptors and thereby inhibiting IL-1 mediated inflammatory signals

Methylation pathway studies

Staging Alzheimers disease risk by sequencing brain function and structure, cerebrospinal fluid, and cognition biomarkers

First, mechanistic studies should combine single-cell spatial transcriptomics with mitochondrial metabolomics to map ferroptosis pathways in spinal ventral horn motor neurons, microglia, and astrocytes, with emphasis on the coupling between NCOA4-mediated ferritinophagy and SOD1/TDP-43 clearance, thereby establishing a dynamic model linking mitochondrial iron dysregulation, proteotoxic stress, and cell death

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Vegetarians and vegans, who do not consume animal products, are also considered at risk of B12 deficiency